Muva nje, i-Desulfovibrio Vulgaris (Desulfovibrio Vulgaris), igciwane elikhiqiza i-acetic acid elisebenza kahle kakhulu, lishicilelwe ku-inthanethi kujenali yamazwe ngamazwe ye-Microbiology yi-Gut Microbes (Isifunda 1). Ibhaktheriya elikhiqiza i-acetic acid enamandla, linciphisa isifo sesibindi esinamafutha angenatshwala kumagundane.

Isifo sesibindi esinamafutha e-non-alcoholic (NAFLD) yisifo esivame kakhulu sesibindi esingapheli, futhi okwamanje kusenokuntuleka kwemithi yokwelapha ephumelelayo. Ucwaningo oluningi luye lwabonisa ukuthi ukuphazamiseka kwe-intestinal microbiota kuyisici esibalulekile ku-pathogenesis yezifo ze-metabolic ezisekelwe ukukhuluphala. Ngakho-ke, ukuqondisa ukulawulwa kwe-microbiota yamathumbu kuthathwa njengesu elisha elibalulekile lokuvimbela nokwelashwa kwezifo ze-metabolic.

Ama-polysaccharides ziwuhlobo lwezinhlanganisela zemvelo ze-macromolecular ezisatshalaliswa kabanzi emithini Yendabuko YamaShayina. Inani elikhulu lezifundo libonise ukuthi i-polysaccharides yezitshalo inemiphumela eqondile ekulawuleni imetabolism, kodwa indlela eqondile ayicacile ngokuphelele. Ithimba lika-Houkai Li libonise ezifundweni ezedlule ukuthi i-astragalus membranaceus polysaccharides, ingxenye eyinhloko esebenzayo ye-astragalus membranaceus, ingathuthukisa ukukhuluphala kanye ne-NAFLD, futhi yabona umphumela wokulawula we-ASTRagalus membranaceus polysaccharides emilanjeni yamathumbu kanye nama-metabolites ngokuhlaziywa kwe-metagenomic metabonomic ehlanganisiwe. I-axis hypothesis ye-"drug-intestinal microbiota - metabolite - host metabolism" yahlongozwa ukuthuthukisa ukwakheka kwe-NAFLD yi-APS.

Ngokusekelwe kulo mbono wesayensi, ithimba labacwaningi lihlole amagciwane athile amathumbu kanye nama-metabolites ahlobene alawulwa yi-APS ngokusebenzisa isu lenhlanganisela ye-multi-omics, futhi lathola ukuthi ukuthuthukiswa kwe-NAFLD nge-APS akugcini nje ngokuba nezici zokuxhomeka kwezitshalo, kodwa futhi kungacebisa kakhulu amathumbu. amagciwane (Desulfovibrio Vulgaris). Ucwaningo olwengeziwe luqinisekisile ukuthi ibhaktheriya lalingeyena nje umkhiqizi wemvelo we-H2S, kodwa futhi lalinekhono eliphumelelayo lokukhiqiza i-acetic acid. Ukwengezwa kwangaphandle kwaleli bhaktheriya kuthuthukise kakhulu i-hepatic steatosis, ukuzwela kwe-insulin kanye nokuzuza kwesisindo kumagundane adla ukudla okunamafutha amaningi. Ngokuhlaziywa kwe-RNA SEQ yesibindi kanye nesifundo se-molecular biology, kwaqinisekiswa ukuthi ukuthuthukiswa kwe-NAFLD kwakuhlobene nokuvinjelwa kwesibindi se-FASN kanye ne-CD36 protein expression. Lolu cwaningo lunikeze ubufakazi obusha bokuchaza indlela ye-APS ekuthuthukiseni i-NAFLD, futhi yanikeza ireferensi yokuhlola indlela ye-APS ekulawuleni izitshalo zamathumbu nokuthuthukisa i-metabolism yokusingatha ngosizo lobuchwepheshe be-multiomics.

Ukuhlaziywa kwezingxenye ze-astragalus polysaccharide monosaccharide kulolu cwaningo kusizwe ithimba likaSolwazi Ding Kan ovela e-Shanghai Institute of Materia Medica, i-Chinese Academy of Sciences, kanye ne-metabolomics ehlosiwe kanye nokwakhiwa kwesihloko kwasekelwa kakhulu ithimba likaSolwazi Jia Wei lasesibhedlela Sesithupha Sabantu esixhumene nabo. e-Shanghai Jiao Tong University. UNingning Zheng kanye no-Wei Jia bangababhali abahambelanayo bephepha. U-Hong Ying, ongenele iziqu zobudokotela eqenjini likaSolwazi Li Houkai, ungumbhali wokuqala wephepha, kanti iShanghai University of Traditional Chinese Medicine ingowokuqala ukusayina leli phepha. Ucwaningo luxhaswe yiNational Natural Science Research Foundation yaseChina.