CoQ10 iyinhlanganisela ekhiqizwa ngokwemvelo ngumzimba ebalulekile ekukhiqizeni amandla eseli futhi isebenza njenge-antioxidant enamandla. Amazinga e-CoQ10 emzimbeni ayancipha ngokuya ngeminyaka. Izinso zidinga amandla abalulekile futhi zithambekele ekucindezelekeni kwe-oxidative, okuzenza zibe sengozini yokulimala ngokuhamba kwesikhathi.

Ngokunikezwa kwemisebenzi ebalulekile ye-CoQ10, abahloli bebelokhu behlola ukuthi I-Coenzyme Q10 ehlanzekile ukwesekwa kungasiza ukusekela impilo ye-oda nokusebenza kwe-oda lekhava, ikakhulukazi kubantu abanezikhalazo zokuhleleka okuvamile noma izifo ezihlobene nokuhleleka ezifana nesifo sikashukela. Lokhu kwakheka kuzonikeza umbono wokuhlolwa kwamanje kwe-CoQ10 nempilo yokuhleleka.

Iqhaza le-CoQ10 Empilweni Yezinso

I-CoQ10 isebenza kakhulu ku-cell mitochondria, izindawo zamandla zamaseli. Njengesithwali se-electron ochungechungeni lokuphefumula lwe-mitochondrial, i-CoQ10 isiza ukushayela ukuhlanganiswa kwe-ATP nokukhiqizwa kwamandla. Izinso zinezidingo zamandla eziphakeme kakhulu kanye nokuqukethwe kwe-mitochondria eminyene, okwenza i-CoQ10 ibaluleke kakhulu ekusebenzeni kwazo.

I-CoQ10 futhi isebenza njenge-antioxidant ephendula i-lipid engamboza ulwelwesi lwamaseli nama-lipoprotein ekulimaleni kwe-oxidative. Ukucindezeleka kwe-oxidative kunomthelela omkhulu ekuhleleni ukulimala. I-CoQ10 ingasiza ekwehliseni ukuvuvukala kanye ne-fibrosis ezimpapheni ngokuphikisa abaguquli bamahhala.

Ngaphezu kwalokho, amazinga e-CoQ10 atholakale ephansi kakhulu ezigulini ezinesifo sezinso esingamahlalakhona uma kuqhathaniswa nabantu abanempilo. Ukubuyisela amazinga e-CoQ10 yeselula kungase kukhuthaze impilo yezinso nokusebenza.

Uhlolojikelele Lwezimo Zezinso

Ezinye izimo ezivamile ezithinta impilo yezinso zihlanganisa:

- Isifo sezinso esingamahlalakhona - ukulahleka kancane kancane kokusebenza kwezinso ngokuhamba kwesikhathi.

- I-Diabetic nephropathy - ukulimala kwezinso okubangelwa isifo sikashukela. Inkinga enkulu yesifo sikashukela.

- Amatshe ezinso - amadiphozithi aqinile akha ezinso.

- Isifo sezinso se-Polycystic - izinso ezikhuliswe ngama-cysts agcwele uketshezi. Isifo sofuzo.  

I-Nephrotic syndrome - izinso zikhipha amaprotheni amaningi emchameni.

- Izifo ze-Urinary tract - izifo ezibangelwa amagciwane kunoma iyiphi ingxenye yesistimu yomchamo.

Ucwaningo luphakamisa ukuthi ukwesekwa kwe-CoQ10 kungasiza ekubambezeleni ukuqhubeka kwezinkinga ezithile zezinso ngokunciphisa ukucindezeleka okwenziwe nge-oxidative, ukuvuvukala, kanye ne-fibrosis. Izifundo ezengeziwe zabantu zisadingeka.

Ukuhlaziywa Kocwaningo Olukhona Nobufakazi

Nakuba imiphumela ngokuvamile ithembisa, izifundo ezinkulu ezilawulwayo zisadingeka ukuze kuqinisekiswe ukusebenza kahle kwe-CoQ10 ekusekeleni impilo yezinso kubantu.

Imiphumela Yokucwaninga Okusemqoka

- Ucwaningo lwezilwane lubonisa ukwesekwa kwe-CoQ10 kunciphisa ukulimala kwezinso kanye ne-fibrosis ngenkathi kuthuthukisa isimo se-antioxidant kanye nomsebenzi we-mitochondrial.

- Olunye ucwaningo lwabantu lwembula ukuthi amazinga e-CoQ10 aphansi kakhulu ezigulini ezinesifo sezinso esingamahlalakhona ezingakabi yi-dialysis uma kuqhathaniswa nezilawuli.

- Izifundo ezimbalwa zabantu ezincane zibika ukuthi i-CoQ10 supplementation ingase ithuthukise ukusebenza kwezinso futhi yehlise i-proteinuria esifweni sezinso esingamahlalakhona.

- Ezigulini ze-hemodialysis, ucwaningo olulodwa lwabika ukuthi i-CoQ10 yehlisa ukuqhubekela phambili kwe-atherosclerosis eminyakeni engu-2.

- Ucwaningo olulodwa kwabanesifo sikashukela lwathola ukuthi i-CoQ10 yehlisa ukwehla kokusebenza kwezinso ngaphezu konyaka ongu-1.

- Akuzona zonke izifundo ezithole inzuzo ecacile ye-CoQ10 supplementation ekuhlolweni kokusebenza kwezinso okujwayelekile njenge-GFR.

- Ayikho imiphumela emibi emibi eye yabikwa nge-CoQ10 supplementation ocwaningweni lwezinso kuze kube manje.

Nakuba amamodeli ezilwane abonisa ngokusobala umphumela wokuvikela izinso we-CoQ10, izifundo ezinkulu zabantu zisadingeka ukuze kuqiniswe izinzuzo kumapharamitha afana nokuncipha kwe-GFR, i-proteinuria, nokuncika kwe-dialysis.

Izindlela Zesenzo Ezingaba Khona

Ezinye izindlela ezihlongozwayo i-CoQ10 ezingazuzisa ngayo izinso zihlanganisa:

- Ukuthuthukisa ukukhiqizwa kwe-ATP ye-mitochondrial kumaseli ezinso anezidingo eziphezulu zamandla. Lokhu kungase kuthuthukise ukusebenza kwezinso.

- Ukunciphisa ukulimala kwe-oxidative ku-lipids, amaprotheni, ne-DNA ezicutshini zezinso ngokukhipha izinhlobo zomoya-mpilo osebenzayo njenge-antioxidant. Ingcindezi ye-oxidative ishayela ukulimala kwezinso.

- Ukucindezela izindlela zokuvuvukala, i-apoptosis, kanye ne-fibrosis eholela ekulimaleni kwamaseli ezinso nokufa.

- Ukuvikela i-endothelium nokunciphisa ukukhula kwe-atherosclerosis ku-vasculature yezinso ukuze kugcinwe ukugeleza kwegazi.

- Ukuthuthukisa ukusebenza kahle kwamanye ama-antioxidants afana ne-vitamin E. I-CoQ10 iphinda igaywe futhi ivuselele uvithamini E.

- Ukwehlisa amazinga omfutho wegazi okungenzeka ngokunciphisa ukumelana ne-peripheral, okuvumela ukugcwala kwezinso okungcono.

Izifundo zomtholampilo ezengeziwe zisadingeka ukuze kuqinisekiswe lezi zindlela zethiyori zihumushela ekuthuthukisweni okuphathekayo ekusebenzeni kwezinso kanye nemiphumela yezempilo.

Izinyathelo Zokuqapha Nezincomo

Uma ucabangela i-CoQ10 ngempilo yezinso, gcina lezi zinyathelo zokuphepha ezilandelayo engqondweni:

- Xhumana nodokotela wakho ngaphambi kokuthatha i-CoQ10, ikakhulukazi uma unesifo sezinso noma usebenzisa i-dialysis, njengoba kungase kudingeke ukulungiswa komthamo.

- Gada ukusebenza kwezinso zakho ngokuhlolwa ngelebhu njengoba kunconywe udokotela wakho. Bika noma yiziphi izinguquko.

- Phuza uketshezi olwanele futhi ulandele iziqondiso zokudla ukuze usekele impilo yezinso.

- Bheka izinhlobo zezithasiselo ezithembekile ezihlinzeka ngohlobo olusebenzayo lwe-CoQ10 olubizwa nge-ubiquinol.

- Nikeza i-CoQ10 okungenani izinyanga ezingu-3-6 ukuze uthole imiphumela emihle yezinso ngemithamo evamile.

- Bhangqa i-CoQ10 namanye ama-antioxidants afana novithamini C, uvithamini E, ne-ALA ukuze uthole izinzuzo ezengeziwe.

- Hlola ukusebenzisana kwezidakamizwa okungenzeka uma uhlanganisa i-CoQ10 nomfutho wegazi noma imithi yesifo sikashukela.

Ngaphansi kokuqondisa kwezokwelapha, i-CoQ10 ivela njengesithasiselo esiphephile esisekela impilo yezinso, kodwa ucwaningo olwengeziwe lusadingeka ukuze kumiswe izivumelwano ezisebenzayo. Ukuqapha ukusebenza kwezinso kuyelulekwa.

I-CoQ10 iyithinta kanjani inhliziyo nezinso?

I-CoQ10 izuzisa kokubili inhliziyo nezinso ngokuyinhloko ngokwenza ngcono ukukhiqizwa kwamandla eselula, iqede ama-radicals mahhala, nokunciphisa ukulimala kwe-oxidative. Inhliziyo nezinso zinezidingo eziphakeme kakhulu zamandla futhi zithambekele ekucindezelekeni kwe-oxidative. I-CoQ10 isekela i-metabolism yamandla enhliziyweni nasezinso ze-mitochondria. Njenge-antioxidant, i-CoQ10 iphinde ivikele izicubu zenhliziyo nezinso ekulimaleni kwama-radical mahhala. Obunye ubufakazi bubonisa ukuthi i-CoQ10 ingasiza futhi ukwehlisa umfutho wegazi. Ukugcina amazinga e-CoQ10 afanele kungasiza ukusekela impilo yalezi zitho ezibalulekile. Nokho, kusadingeka izifundo ezinkulu.

Kungani odokotela bengayincomi i-CoQ10?

Kunezizathu ezimbalwa zokuthi kungani ukwesekwa kwe-CoQ10 kungase kunganconyelwe yibo bonke odokotela:

- Izivivinyo zomtholampilo zesilinganiso esikhulu zisadingeka ukuze kuqinisekiswe imiphumela yokwelapha kubantu. Ubufakazi bulinganiselwe.

- Amasu omthamo alungile ezimeni ezithile ahlala engacacile.

- Iziqondiso ezijwayelekile zokuzijwayeza azikafaki i-CoQ10 ngenxa yobufakazi obanele.

- Abanye odokotela bangase bakhethe ukugxila emithini nasekushintsheni kwendlela yokuphila ngokusebenza ngempumelelo okuqinisekisiwe.

- Ukulawulwa kwezithasiselo kushoda, okuphakamisa ukukhathazeka mayelana nokulawulwa kwekhwalithi nokunemba kokulebula.

- Idatha yokuphepha yesikhathi eside kubantu abaningi inomkhawulo.

- I-CoQ10 ayimboziwe umshwalense, okwenza izindleko zibe isithiyo esingaba khona.

Nokho, izimo zengqondo ziyashintsha njengoba kuvela izilingo ezilawulwa kakhulu. Abanye odokotela abacabanga phambili bayaphakamisa ukwesekwa kwe-CoQ10 ezimweni ezithile, ikakhulukazi uma amazinga ephansi. Kodwa-ke, ucwaningo olwengeziwe kanye nokulawulwa kusadingeka ngokujwayelekile ukuze kwamukelwe okujwayelekile.

Ubani okungafanele adle i-CoQ10?

Izithasiselo ze-CoQ10 zithathwa njengephephile kubantu abaningi ngemithamo evamile. Kodwa-ke, abantu abathile kufanele baqaphele ngokusetshenziswa kwe-CoQ10:

- Abesifazane abakhulelwe noma abancelisayo, njengoba idatha yokusetshenziswa ilinganiselwe.

- Abantu abahlelelwe ukuhlinzwa emasontweni angu-2 alandelayo, njengoba i-CoQ10 ingase ibe mncane igazi.

- Abantu abathatha ama-anticoagulant njenge-warfarin, njengoba i-CoQ10 ingase inyuse ingozi yokopha. Ukuqapha ngokucophelela isimo se-blood coagulation kuyelulekwa uma usebenzisa kokubili.

- Abantu abanesifo sesibindi noma ukwehluleka, njengoba isibindi sihilelekile ku-CoQ10 synthesis.

- Izingane, ngenxa yokuntuleka kwedatha yokuphepha.

- Abantu abanomdlavuza we-melanoma noma webele, njengoba kudingeka ucwaningo olwengeziwe mayelana nemiphumela ye-CoQ10 kula mdlavuza.

- Abantu abane-coenzyme Q10 hyperoxaluria, isimo esingavamile sofuzo.

Noma ubani onezimo zezempilo ezibalulekile kufanele abonane nodokotela wakhe ngaphambi kokungeza nge-CoQ10 ukuze uthole isiqondiso esithile.

Yiziphi izimpawu zokudinga i-CoQ10?

Azikho izimpawu eziqondile ezihlala zibonisa isidingo se-CoQ10 supplementation. Kodwa-ke, ezinye zezimpawu ezingaba khona zokushoda kwe-CoQ10 zifaka:

- Ukukhathala, ubuthakathaka, noma ukunciphisa ukubekezelelana kokuzivocavoca.

- Ubuhlungu bemisipha, ubuhlungu noma amajaqamba.

- Ukusetshenziswa kwezidakamizwa ze-statin. I-Statins iqeda i-CoQ10.

- Izimpawu ze-neurological njengokundindizela, isiyezi, noma ikhanda elibuhlungu.

- Umfutho wegazi ophezulu.

- Ukuhluleka kwenhliziyo eqinile.

- Ukuphazamiseka kweMitochondrial.

- Ukuphazamiseka kwezinso njengesifo sezinso esingamahlalakhona.

- Izinkinga zokungazali kwabesilisa noma abesifazane.

- Ukuncipha kwengqondo noma isifo se-neurodegenerative.

Ukuhlola amazinga egazi e-CoQ10 kungaqinisekisa isimo esiphansi ngokomtholampilo. Kodwa-ke, abaningi abanamazinga e-CoQ10 ajwayelekile basathola izinzuzo ekungezeleni. Labo abathintekayo kufanele baxoxe ngokuhlolwa nokwesekwa nodokotela wabo.

Yikuphi okungcono ngenhliziyo ye-CoQ10 noma uwoyela wezinhlanzi?

Kokubili i-CoQ10 namafutha ezinhlanzi kuzuzisa impilo yenhliziyo, kodwa ngezindlela ezahlukene. Umdwebo kawoyela wezinhlanzi uhlinzeka ngamafutha e-omega-3-3 i-EPA ne-DHA, enciphisa ukuvuvukala, i-triglycerides ephansi, futhi ingase ithuthukise izinkinga zenhliziyo nemithambo yegazi. I-CoQ10 ithuthukisa imikhiqizo yamandla eselula, isebenza njenge-antioxidant, futhi ibamba iqhaza elibalulekile kumetabolism yamangqamuzana enhliziyo. Ukuze uthole ukwesekwa okuphelele kwempilo yenhliziyo, kokubili kubonakala kuyahambisana. Ezinye izifundo zisebenzisa kokubili amafutha ezinhlanzi kanye ne-CoQ10. Imiphumela emihle yenhliziyo ingase idinge ukuthathwa okwanele kwakho kokubili i-EPA/DHA ne-CoQ10. Ezigulini ezisengozini enkulu noma lezo ezinesifo senhliziyo, okokufaka kukadokotela ekusetshenzisweni kahle kwazo zombili izithasiselo kuyelulekwa.

Isiphetho

Kafushane, i-CoQ10 ikhombisa isithembiso esikhulu sokusekela impilo yezinso nokusebenza okusekelwe ezindimeni zayo ezibalulekile kumetabolism yamandla kanye nomsebenzi we-antioxidant. Ucwaningo lwamaseli nezilwane luveza imiphumela ekhuthazayo yokuvikela izinso. Ucwaningo lwabantu olusezingeni elincane lubika izinzuzo zesifo sezinso esingamahlalakhona, isifo sikashukela, kanye neziguli ze-dialysis. Kodwa-ke, izivivinyo zomtholampilo eziqinile ezinezivumelwano ezithuthukisiwe zisadingeka, ikakhulukazi mayelana nomthamo, ubude besikhathi, kanye nemiphumela. Sebenza ne-nephrologist ukuze uthole isiqondiso lapho usebenzisa i-CoQ10 impilo yezinso. Nakuba imiphumela engemihle iphansi, thatha izinyathelo zokuphepha nganoma yiziphi izimo zezokwelapha noma imithi. Ucwaningo luyaqhubeka nokuvela, kodwa i-CoQ10 njengendlela yokwelapha ehambisanayo ibonakala inengqondo kubantu abathile abafuna ukuthuthukisa ukusebenza kwezinso nokuhamba kancane kwesifo. Izivivinyo ezinkulu maduze zinganikeza ubufakazi obuqinisekile.

I-Hubei Sanxin Biotechnology Co., Ltd. ihlanganise ucwaningo nentuthuko, ukukhiqiza, nokuthengisa iminyaka eminingi. Singathembekile kuwe I-Coenzyme Q10 ehlanzekile umthengisi. Singahlinzeka ngezinsizakalo ezenziwe ngokwezifiso njengoba ucela.

Email: nancy@sanxinbio.com

Okubhekwayo

1. Aminzadeh, MA, & Vaziri, ND (2018). Ukulawulwa phansi kochungechunge lwezokuthutha lwe-electron mitochondrial esifweni sezinso esingamahlalakhona. Kidney International, 94(2), 258–266. https://doi.org/10.1016/j.kint.2018.02.013

2. Yeung, CK, Billings, FT, Claes, D., Roshanravan, B., Roberts, LJ, Himmelfarb, J., Ikizler, TA, & Group, C.-TS (2015). Ucwaningo lwe-Coenzyme Q10 lokwenyuka komthamo ezigulini ze-hemodialysis: ukuphepha, ukubekezelelana, kanye nomthelela ekucindezelekeni kwe-oxidative. I-BMC nephrology, 16, 183. https://doi.org/10.1186/s12882-015-0173-4

3. Hodroge, A., Drozdz, M., Smani, T., Hemmeryckx, B., Rawashdeh, A., Avkiran, M., & Amoui, M. (2021). Imiphumela yokuvikela ye-coenzyme Q10 ngokumelene ne-nephropathy yesifo sikashukela: Ukubuyekezwa okuhlelekile kwezifundo ze-in vitro kanye ne-vivo. Ama-Biomolecules, 11(8), 1166. https://doi.org/10.3390/biom11081166

4. Ivanov VT et al. (2017) Imiphumela ye-micro disperse Coenzyme Q10 formulation on statin-related myopathy izimpawu ezigulini ezinesifo sikashukela: Isivivinyo esilawulwa ngokungahleliwe, Imithetho ye-Endocrine, 51:4, 206-212, DOI: 10.1515/enr-2017-0026

5. Mortensen SA et al (2014). I-Coenzyme Q10: izinzuzo zomtholampilo ezine-biochemical correlates eziphakamisa impumelelo yesayensi ekulawulweni kokwehluleka kwenhliziyo okungapheli, I-International Journal of Cardiology, 175:3, 56-61. https://doi.org/10.1016/j.ijcard.2014.05.011.

6. Yeung, CK, Billings, FT, Claes, D., Roshanravan, B., Roberts, LJ, Himmelfarb, J., Ikizler, TA, & Group, C.-TS (2016). Ucwaningo lokwenyuka komthamo we-Coenzyme Q10 ezigulini ze-hemodialysis: ukuphepha, ukubekezelelana, kanye nomthelela ekucindezelekeni kwe-oxidative. I-BMC nephrology, 17, 64. https://doi.org/10.1186/s12882-016-0257-y

7. U-Zhang, Y., Wang, L., Zhang, J., Xi, T., LeLan, F., & Li, Z. (2020). Umthelela we-Coenzyme Q10 Ezigulini Ezinesifo Se-Diabetic Nephropathy: Ukuhlaziywa Kwe-Meta Yezilingo Ezilawulwa Ngokungahleliwe. Imingcele ku-pharmacology, 11, 108. https://doi.org/10.3389/fphar.2020.00108